Low-Level Electrical Stimulation of Aortic€Root Ventricular Ganglionated Plexi€Attenuates Autonomic Nervous System–Mediated Atrial Fibrillation
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چکیده
METHODS Effective refractory periods (ERPs) of test pulmonary veins (PVs) were measured at baseline and during highlevel (HL-ES) and low-level (LL-ES) electrical stimulation of the aortic root GP. The arrhythmogenic threshold of acetylcholine and isoproterenol was determined at baseline and during HL-ES and LL-ES. Moreover, AF was induced at PVs by programmed electrical stimulation after HL-ES or LL-ES. Immunohistochemistry staining was performed to examine the autonomic activity from aortic root GP to the PVs.
منابع مشابه
Ganglionated plexi modulate extrinsic cardiac autonomic nerve input: effects on sinus rate, atrioventricular conduction, refractoriness, and inducibility of atrial fibrillation.
OBJECTIVES This study sought to systematically investigate the interactions between the extrinsic and intrinsic cardiac autonomic nervous system (ANS) in modulating electrophysiological properties and atrial fibrillation (AF) initiation. BACKGROUND Systematic ganglionated plexi (GP) ablation to evaluate the extrinsic and intrinsic cardiac ANS relationship has not been detailed. METHODS The ...
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An autonomic imbalance, i.e., increased sympathetic tone and/or decreased parasympathetic tone is a critical characteristic of heart failure, which is associated with progressive ventricular remodeling, ventricular arrhythmia generation and disease progression. Increasing cardiac parasympathetic tone by vagus nerve stimulation has been shown to significantly improve heart failure symptoms, hemo...
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The rise of vagal tone facilitated the activity of pulmonary veins and played an important role in the initiation of AF [1]. Autonomic nerve stimulation shortens AERP, decreases the wavelength of atrial reentrant circuits and increases dAERP, thus, promoting the stability of AF [2]. Several studies have demonstrated that additional ablation of epicardiol ganglionated plexi (GP) improved success...
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تاریخ انتشار 2015